2. Signaling Pathways
  3. PROTAC
  4. PROTAC Linkers

PROTAC Linkers

PROTAC Linkers

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PROTACs (Proteolysis Targeting Chimeric Molecules) are heterobifunctional protein degraders and promising targeted therapeutics candidates for cancer. The PROTAC linker connects two functional motifs of a PROTAC, a target protein binder and an E3 ligase recruiter.

The linker plays an important role in a PROTAC. The features of the linker (type, length, attachment position) can affect the formation of ligase:PROTAC:target ternary complex, resulting in influencing the efficient ubiquitination of the target protein and its ultimate degradation. The optimal lengths of the PROTAC linkers are reported varying from 12-carbon to over 20-carbon, and the commonly used linkers in the development of PROTACs are PEGs, Alkyl-Chain and Alkyl/ether.

PROTAC Linkers Isoform Specific Products:

PROTAC Linkers Isoform Comparison
Cat. No. Product Name CAS No. Purity Chemical Structure
  • HY-130396
    DBCO-PEG4-C2-acid 1537170-85-6 99.22%
    DBCO-PEG4-C2-acid is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs. DBCO-PEG4-C2-acid is a click chemistry reagent, it contains a DBCO group that can undergo strain-promoted alkyne-azide cycloaddition (SPAAC) with molecules containing Azide groups.
    DBCO-PEG4-C2-acid
  • HY-W190962
    t-Boc-N-amido-PEG5-acetic acid 890152-41-7 99.91%
    BocNH-PEG5-acid is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs.
    t-Boc-N-amido-PEG5-acetic acid
  • HY-W008879
    Mal-amido-PEG6-NHS ester 1137109-21-7 98.76%
    Mal-amido-PEG6-NHS ester is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs.
    Mal-amido-PEG6-NHS ester
  • HY-135911
    Biotin-PEG2-OH 717119-80-7 98.0%
    Biotin-PEG2-OH is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs.
    Biotin-PEG2-OH
  • HY-138734
    Propargyl-PEG2-NHS ester 2512228-06-5 ≥98.0%
    Propargyl-PEG2-NHS ester is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs. Propargyl-PEG2-NHS ester is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.
    Propargyl-PEG2-NHS ester
  • HY-140222
    Amino-PEG2-C2-hydrazide-Boc 2100306-60-1
    Amino-PEG2-C2-hydrazide-Boc is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs.
    Amino-PEG2-C2-hydrazide-Boc
  • HY-133066
    m-PEG6-NHS ester 1449390-12-8
    m-PEG6-NHS ester is a non-cleavable 6 unit PEG ADC linker used in the synthesis of antibody-drug conjugates (ADCs). m-PEG6-NHS ester is a PEG/Alkyl/ether-based PROTAC linker can be used in the synthesis of PROTACs.
    m-PEG6-NHS ester
  • HY-W012862
    Methyl-PEG2-alcohol 111-77-3 99.97%
    Methyl-PEG2-alcohol is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs.
    Methyl-PEG2-alcohol
  • HY-141120
    Boc-NH-PEG10-NHS ester 3075546-11-8 98.0%
    Boc-NH-PEG10-NHS ester is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs.
    Boc-NH-PEG10-NHS ester
  • HY-133231
    Bis-PEG10-acid 2055023-26-0 ≥98.0%
    Bis-PEG10-acid is a PEG-based PROTAC linker can be used in the synthesis of PROTACs.
    Bis-PEG10-acid
  • HY-140228
    m-PEG24-NH2 2151823-08-2 99.96%
    m-PEG24-NH2 is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs.
    m-PEG24-NH2
  • HY-35261A
    Mal-PEG2-NH2 TFA 660843-23-2 99.79%
    Mal-PEG2-NH2 (TFA) is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs.
    Mal-PEG2-NH2 TFA
  • HY-140759
    Azido-PEG10-NHS ester 2801772-86-9 98.03%
    Azido-PEG10-NHS ester is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs. Azido-PEG10-NHS ester is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups.
    Azido-PEG10-NHS ester
  • HY-130213
    Thiol-PEG4-acid 749247-06-1
    Thiol-PEG4-acid is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs.
    Thiol-PEG4-acid
  • HY-130376
    Propargyl-PEG8-NHS ester 2182601-74-5
    Propargyl-PEG8-NHS ester is a PEG/Alkyl/ether-based PROTAC linker can be used in the synthesis of PROTACs. Propargyl-PEG8-NHS ester is a cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs). Propargyl-PEG8-NHS ester is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.
    Propargyl-PEG8-NHS ester
  • HY-126890
    Bis-PEG7-NHS ester 1334170-02-3 98.0%
    Bis-PEG7-NHS ester is a PEG/Alkyl/ether-based PROTAC linker can be used in the synthesis of PROTACs. Bis-PEG7-NHS ester is a cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs).
    Bis-PEG7-NHS ester
  • HY-130151
    m-PEG7-CH2CH2COOH 1093647-41-6 99.39%
    m-PEG7-CH2CH2COOH is a non-cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs). m-PEG7-CH2CH2COOH is also a PEG-based PROTAC linker that can be used in the synthesis of PROTACs.
    m-PEG7-CH2CH2COOH
  • HY-134687
    Iodoacetamide-PEG5-azide 98.58%
    Iodoacetamide-PEG5-azide is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs. Iodoacetamide-PEG5-azide is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups.
    Iodoacetamide-PEG5-azide
  • HY-140194
    Amino-PEG5-Boc 1446282-18-3 98.0%
    Amino-PEG5-Boc is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs.
    Amino-PEG5-Boc
  • HY-W018023
    Bis(2,5-dioxopyrrolidin-1-yl) succinate 30364-60-4
    Bis(2,5-dioxopyrrolidin-1-yl) succinate is a PROTAC linker that can be used in the synthesis of PROTACs.
    Bis(2,5-dioxopyrrolidin-1-yl) succinate
PROTAC Linkers Isoform Comparison

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